A: Yes. Any drug or medication that suppresses normal activity of the Central Nervous System (sedatives, anti-anxiety meds, blood pressure stabilizers, etc.) will reduce the strength of reactions found on the polygraph charts, resulting in a higher likelihood of inconclusive results. The medications will not change the outcome of an exam and only serve to reduce the odds of resolving the problem. It would be our suggestion to test any person who is using these types of drugs or medications on a computerized polygraph which is capable of greater sensitivity than the analog version.